ALX148, Rituximab and Lenalidomide for the Treatment of Indolent and Aggressive B-cell Non-Hodgkin Lymphoma

Inclusion Criteria: * Phase I: histologically confirmed B-cell NHL, including marginal zone lymphoma, follicular lymphoma, mantle cell lymphoma, large B-cell lymphoma (including transformed MZL, transformed FL, Richter Syndrome with ALC \< 5,000 109/L, FL grade 3B, high grade B-cell lymphoma and primary mediastinal B-cell lymphoma), and composite lymphoma (concomitant indolent and aggressive B-NHL) * Phase I: have failed at least one line of systemic therapy and not be eligible for known standard of care curative treatment option; patients with mantle cell lymphoma and aggressive B-cell lymphoma will need to have received 2 prior lines of systemic therapy. * Phase II: histologically confirmed follicular lymphoma, grade 1, 2, or 3a or marginal zone lymphoma * Phase II: have had no prior systemic treatment for lymphoma * Phase II: high tumor burden disease, defined by meeting 1 or more of the following GELF criteria * Bulky disease defined as: a nodal or extranodal (except spleen) mass \>7cm in its greater diameter or, involvement of at least 3 nodal or extranodal sites (each with a diameter greater than \>3 cm) * Presence of at least one of the following B symptoms: fever (\>38C) of unclear etiology, night sweats, weight loss greater than 10% within the prior 6 months * Symptomatic splenomegaly * Impending organ compression or involvement * Any one of the following cytopenias due to lymphoma: hemoglobin \< 10 g/dL (6.25 mmol/L), platelets \< 100 x 10\^9/L , or abso…