The Effect of Exercise and Nicotinamide Riboside Muscle Health and Insulin Resistance in Survivor… (NCT05023993) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
The Effect of Exercise and Nicotinamide Riboside Muscle Health and Insulin Resistance in Survivors of Childhood Cancer
United States20 participantsStarted 2022-06-23
Plain-language summary
This trial studies the effect of exercise and nicotinamide riboside on muscle health and insulin resistance in adult survivors of childhood cancer with prediabetes (elevated blood sugar level that is not high enough to be considered diabetes). Nicotinamide riboside is a dietary supplement which is similar to vitamin B3. Information collected in this study may help the future development of regimens to improve metabolic outcomes such as muscle health and insulin resistance (when the body is not normally responding to insulin) in childhood cancer survivors.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* History of childhood cancer
* History of prediabetes (HbA1c 5.7-6.4%)
* In remission at time of enrollment
* Time between completion of cancer-directed therapy and study entry: \>= 6 months
* At least 18 years of age at time of enrollment
* Able to access online exercise program at home
* Ability to tolerate the prescribed resistance exercise program
* English-speaking
* Able to understand and sign the study specific informed consent form (ICF)
Exclusion Criteria:
* Taking a nicotinamide adenine dinucleotide (NAD)+ precursor in the two weeks prior to enrollment
* Currently taking medication for hyperglycemia or diabetes
* Females who are pregnant or planning to become pregnant
* Currently recovering from an injury
* Contraindication to magnetic resonance imaging (MRI)
* Pacemaker
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Feasibility of a nutrition and exercise program in childhood cancer survivors (CCS)