CompletedPhase 4

Optimization Strategy for the Prevention of AMS by RIPC Combined With Acetazolamide

China252 participantsStarted 2021-12-01

Plain-language summary

The primary objective of the study will be to determine whether rapid remote limb ischemic preconditioning (RIPC) combined with acetazolamide can further reduce the incidence of acute mountain sickness (AMS) during the 6-hour hypoxic chamber.

Who can participate

Age range

18 Years – 50 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * People who live in plain areas all year round and have not been to an altitude of 1500 meters or more in the past 30 days; * Sign the informed consent form voluntarily. Exclusion Criteria: * Chronic physical or mental diseases, including hypertension, diabetes, coronary heart disease, cerebrovascular disease, chronic obstructive pulmonary disease, migraine, anxiety, depression, insomnia, etc.; * The female is pregnant or in the period of preparing for pregnancy or breast-feeding; * Have a history of smoking; * Have a history of thrombosis in the upper limbs; * Severe damage to local soft tissues of upper limbs, fractures, etc.; * Allergic to sulfa; * Are taking one or more drugs; * Past laboratory tests suggest hypokalemia, hyponatremia, or liver and kidney damage; * Patients unsuitable for enrollment in the clinical trial according to investigators decision making.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

The incidence of acute mountain sickness.

Timeframe: 6 hours after entering the hypoxic room.

The severity of acute mountain sickness.

Timeframe: 6 hours after entering the hypoxic room.

Fingre pulse oximetry of the subjects.

Timeframe: 6 hours after entering the hypoxic room.

Trial details

NCT IDNCT05023941

SponsorJi Xunming,MD,PhD

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-08-22

View on ClinicalTrials.gov More Acute Mountain Sickness trials

Who can participate

Age range

18 Years – 50 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.