UnknownNot Applicable

Non-invasive Placental Chromosome Exploration of Intrauterine Growth Restriction

France300 participantsStarted 2021-10-05

Plain-language summary

The objective of this project is the non-invasive prenatal detection of placenta-limited aneuploidies, in patients whose fetuses have a intrauterine growth restriction below 3rd percentile, in parallel with an amniocentesis. This study will allow the chromosomal study of the placenta in pregnant women whose genetic prenatal diagnosis, made by amniocentesis, does not allow exploring the placental causes of fetal RCIU.

Who can participate

Age range18 Years

SexFEMALE

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Inclusion Criteria: * over 18 years old, * treated in the DDIANE fetal medicine centre at the Bordeaux University Hospital, * having a fetus with IUGR diagnosis below the 3rd percentile (after reference medical ultrasound), * from 16 weeks of amenorrhea or more, * accepting an Invasive Prenatal Diagnosis by amniocentesis with array comparative genomic hybridization Exclusion Criteria: Childbearing women who: * do not accept a non-invasive prenatal diagnosis (amniocentesis) * have a fetus with non-isolated IUGR (associated with other ultrasound signs) * do not consent to participate in the research protocol

What they're measuring

Determine the presence or absence of chromosomal abnormality in the plasma sample. studied.

Timeframe: Inclusion date

Trial details

NCT IDNCT05023161

SponsorUniversity Hospital, Bordeaux

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-10-05

Contact for this trial

Caroline THAMBO

05 56 79 59 52 caroline.rooryck-thambo@chu-bordeaux.fr

View on ClinicalTrials.gov More Fetal Growth Retardation trials