UnknownNot Applicable

Type I Collagen Fragments in the GCF and Saliva During OTM

Egypt14 participantsStarted 2021-05-15

Plain-language summary

Investigate the levels of type I Collagen fragments ICTP and CTX in GCF and saliva during initial leveling and alignment of the teeth in a sample of adolescents undergoing orthodontic treatment.

Who can participate

Age range13 Years – 18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * The age ranges from 13-18 years old. * Good oral hygiene. * Clinical gingival health on the intact periodontium. * Permanent dentition. * Moderate crowding. * Non-extraction treatment plan. If extraction of teeth is required, the treatment plan should allow for postponing extraction after sample collection. Exclusion Criteria: * Systemic diseases associated with loss of periodontal supporting tissues. * Metabolic bone diseases and systemic medications affecting bone metabolism. * Craniofacial anomalies such as cleft lip and/or palate. * Xerostomia. * Tobacco-related habits such as smoking, tobacco chewing, etc.

What they're measuring

Levels of ICTP in GCF and saliva samples before appliance placement, 24 hours, 3 days, 7 days, 14 days, and 21 days after archwire placement.

Timeframe: 21 days

Levels of CTX in GCF and saliva samples before appliance placement, 24 hours, 3 days, 7 days, 14 days, and 21 days after archwire placement.

Timeframe: 21 days

Trial details

NCT IDNCT05020431

SponsorAlexandria University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-11-15

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