This study will be a longitudinal multiple-visit observational study, done to identify possible bioindicators of recovery and repair of motor corticospinal pathways which may be targeted by future interventions in infants with perinatal stroke. 65 participants will be recruited and complete 1 visit at time point 1 (0-2 months), and 2 visits at each timepoints 2-5 with windows of +- 4 weeks (3-6 months, 12 months, 18 months and 24 months). Visits will consist of Magnetic Resonance Imaging (MRI) assessment during the child's natural sleep, Transcranial Magnetic Stimulation (TMS), and Motor Behavioral Assessments.
Age range
0 Years – 24 Months
Sex
ALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Change in Cortical excitability measured as presence/absence of motor evoked potentials (MEP)
Timeframe: 3-6 months (one visit in this time frame), 12±1 months, 18±1 months, 24±1 months
Change in Cortical excitability measured by intensity of motor threshold (MT)
Timeframe: 3-6 months (one visit in this time frame), 12±1 months, 18±1 months, 24±1 months
Change in Mean Fractional Anisotropy (FA) within the CST
Timeframe: 1 ±1 month, 3-6 months (one visit in this time frame), 12±1 months, 18±1 months, 24±1 months
Behavioral assessments: General Movements Assessment (GMA) reported on binary (Y/N) scale
Timeframe: 1 ±1 month
Behavioral assessments: General Movements Assessment (GMA) reported on binary (Y/N) scale
Timeframe: 3 ±1 months
Behavioral assessments: Hammersmith Infant Neurological Examination (HINE) global score
Timeframe: 1 ±1 month
Behavioral assessments: Hammersmith Infant Neurological Examination (HINE) global score
Timeframe: 3-6 months (one visit in this time frame)
Behavioral assessments: Hammersmith Infant Neurological Examination (HINE) global score
Timeframe: 12±1 months
Behavioral assessments: Hammersmith Infant Neurological Examination (HINE) global score
Timeframe: 18±1 months
Behavioral assessments: Hammersmith Infant Neurological Examination (HINE) global score
Timeframe: 24±1 months
Behavioral assessments: Hammersmith Infant Neurological Examination (HINE) Asymmetry Scores
Timeframe: data collected at 1 ±1 month, 3-6 months (one visit in this time frame), 12±1 months, 18±1 months, 24±1 months
Behavioral assessments: Bayley Scales of Infant and Toddler Development Test, 4th edition (Bayley-4) score
Timeframe: 3-6 months (one visit in this time frame)
Behavioral assessments: Bayley Scales of Infant and Toddler Development Test, 4th edition (Bayley-4) score
Timeframe: 12±1 months
Behavioral assessments: Bayley Scales of Infant and Toddler Development Test, 4th edition (Bayley-IV) score
Timeframe: 18±1 months
Behavioral assessments: Bayley Scales of Infant and Toddler Development Test, 4th edition (Bayley-4) score
Timeframe: 24±1 months
Baby Observation of Selective Control AppRaisal (Baby OSCAR)
Timeframe: 1±1 month
Baby Observation of Selective Control AppRaisal (Baby OSCAR)
Timeframe: 3-6 months (one visit in this time frame)
Change in Pediatric Evaluation of Disability Inventory Computer Adaptive Test (PEDI-CAT)
Timeframe: 1 ±1 month, 3-6 months (one visit in this time frame), 12±1 months, 18±1 months, 24±1 months