CompletedNot Applicable

Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine

United States9 participantsStarted 2022-05-01

Plain-language summary

This study is an observational longitudinal study involving the use of MRIs and video recordings taken at home of patients completing basic tasks. Once consent is obtained, subjects will be asked to schedule an appointment with radiology to undergo the listed MRIs of the heart and/or muscle. Subjects will also be given instructions on how to use the video recording app on their personal devices, or study provided device. The subjects will be followed regularly over the course of two years, submitting video recordings of their movements and reporting to Mayo Clinic for MRIs as scheduled.

Who can participate

Age range15 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Confirmed or suspected primary mitochondrial disorder \*Suspected mitochondrial disorder would mean that the patient meets clinical criteria and has either biopsy or biochemical testing that supports the diagnosis. Exclusion Criteria: * Pregnant, breastfeeding * Severe cardiac disease who are unable to undergo all the required testing * Requiring anesthesia for MRIs * Has severe claustrophobia * Has implanted devices

What they're measuring

Indicators of disease severity and progression - cardiac movement

Timeframe: 2 years

Indicators of disease severity and progression - cardiac function

Timeframe: 2 years

Indicators of disease severity and progression - skeletal muscle function

Timeframe: 2 years

Indicators of disease severity and progression - skeletal muscle movement

Timeframe: 2 years

Trial details

NCT IDNCT05012358

SponsorMayo Clinic

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-01-22

View on ClinicalTrials.gov More Mitochondrial Myopathies trials