Surgical Treatments for Postamputation Pain

Inclusion Criteria: * The participant must have a major limb amputation. * The participant is ≥ 18 years old at the time of consent. * The participant must be in generally good health to undergo a surgical intervention, as per the clinical investigator's opinion. * Time since the last amputation must be over a year at the time of consent. * The participant must have an average residual limb pain score equal or greater than 4 on the Numerical Rating Scale (NRS, 0-10) after the baseline period. * If the participant has been prescribed pharmacological treatments for pain, there must be no variations in dosage (steady consumption) for at least 1 month before the screening visit. * If the participant has been prescribed non-pharmacological treatments for pain, such as spinal cord stimulation, transcutaneous electrical nerve stimulation, and mirror therapy, the treatment must have ended at least 1 month before the screening visit. * The participant must have a stable prosthetic fitting for at least a month before the screening visit. * The participant has a sufficient understanding of the language in which the assessments will be conducted, as per the clinical investigator's opinion. Exclusion Criteria: * Neurological or other conditions that affect nerve regeneration for the nerve to be treated. * Active infection in the residual limb. * Prior RPNI or TMR surgery of the nerve to be treated (with painful neuroma) to address postamputation pain. * Mental disorders (e.g., schizoph…