RecruitingNot Applicable

Laser Photocoagulation of Communicating Vessels in Twin-to-Twin Transfusion Syndrome

United States2,000 participantsStarted 2021-10-01

Plain-language summary

The purpose of this study is to evaluate the use of diode laser photocoagulation of the communicating vessels in twin-to- twin transfusion syndrome (TTTS) with respect to maternal, fetal and neonatal outcomes.

Who can participate

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Single placenta (Monochorionic) * Polyhydramnios present in recipient twin (Greater than 8 cm maximum vertical pocket below 20 weeks and greater than a 10 cm pocket for greater than 20 weeks gestational age) * Oligohydramnios present in donor twin (Less than 2 cm maximum vertical pocket) * Prominent bladder in the recipient/ non-filling bladder in the donor * Thin dividing membrane Exclusion Criteria: * Patients unwilling to participate in the study or to be followed up * Presence of major congenital anomalies incompatible with survival * Active pre-term labor Ruptured membranes * Chorioamnionitis * Vaginal bleeding

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Survival

Timeframe: Immediately after the surgery to discharge from the hospital after delivery

Trial details

NCT IDNCT05008744

SponsorSeattle Children's Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2031-10-01

Contact for this trial

Martin P Walker, MD

206-987-3539 martin.walker@seattlechildrens.org

View on ClinicalTrials.gov More Twin to Twin Transfusion as Antepartum Condition trials

Who can participate

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.