Pancreatic Cancer Screening for At-risk Individuals

Inclusion criteria

• ✓. Familial Pancreatic cancer kindred. This is defined as family history of pancreas cancer that meet the criteria listed below.
• ✓. If at least two affected relatives who are First degree relatives (FDR) to each other, of whom at least one is an FDR to the individual considered for surveillance
• ✓. If at least three affected relatives on the same side of the family, of whom at least one is an FDR to the individual considered for surveillance
• ✓. If at least two affected relatives on the same side of the family, of whom at least one is an FDR to the individual considered for surveillance Screening is usually initialed at age 50 years or 10 years younger than the youngest family member with pancreatic cancer
• ✓. Patients with genetic susceptibility to pancreas cancer
• ✓. Patients with Peutz-Jeghers syndrome diagnosed with using clinical criteria or with a deleterious mutation in liver kinase B1/Serine/threonine kinase 11 (LKB1/STK11). Screening is usually initiated at age 40 years or later.
• ✓. Patients with Familial Atypical Multiple Mole Melanoma Syndrome (FAMMM syndrome), diagnosed using clinical criteria or CDKN2A p16 mutation.
• ✓. Hereditary Breast and Ovarian Cancer syndrome: diagnosed using clinical criteria or deleterious Breast Cancer gene 1 (BRCA1), Breast Cancer gene 2 (BRCA2), Partner and Localizer of BRCA2 (PALB2). The usual indication for screening is: