CompletedNot Applicable

Verification of Risk Assignment for Whole Chromosome Using SNP-based NIPT in Vanishing Twin Pregnancies

United States126 participantsStarted 2021-07-22

Plain-language summary

The purpose of this study is to collect blood samples from women carrying a vanishing twin pregnancy to further develop Natera's non-invasive prenatal screening test to provide information about possible chromosomal conditions for the living twin

Who can participate

Age range18 Years

SexFEMALE

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Inclusion Criteria: * Women with either ultrasound-documented dizygotic (DZ) twin pregnancy or those whose Panorama Test™ results suggest increased risk for vanishing twin Exclusion Criteria: * Monozygotic twin pregnancy * Non twin pregnancy * Maternal history of bone marrow or organ transplantation

What they're measuring

Develop a new algorithm and methodology that will measure fetal fraction and distinguish between the DT (demised/non-viable twin) and living twin (LT) in dizygotic twins (DZ) with a single LT.

Timeframe: 2 years

The accuracy of the new algorithm to determine which of the signals in the Panorama samples correspond to the LT versus the DT.

Timeframe: 2 Years

Trial details

NCT IDNCT05004337

SponsorNatera, Inc.

Sponsor typeINDUSTRY

Study typeOBSERVATIONAL

Primary completion2023-11-29

View on ClinicalTrials.gov More Vanishing Twin trials