CompletedPhase 1/2

Concentrated Growth Factors in Treatment of Intrabony Defects in Localized Aggressive Periodontitis

Egypt10 participantsStarted 2020-07-01

Plain-language summary

A total of 20 intra-bony defects in 10 LAP patients were randomly assigned into two groups 10 defects each in a split-mouth design. Group I treated by surgery plus Bio-Oss bone graft + collagen membrane (Control group). Group II, treated by surgery plus Bio-Oss bone graft + CGF membrane (Test group). Gingival index (GI), bleeding on probing (BOP), probing pocket depth and clinical attachment level (CAL) were assessed at baseline, 3, 6, and 12 months. Cone beam radiograph evaluation was taken at baseline, and 12 months after surgery..

Who can participate

Age range20 Years – 45 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Presence of angular periodontal intra-bony defects with clinical attachment loss ≥5 mm measured from CEJ to the deepest propping depth with no evidence of gingival recession * optimal compliance as evidenced by no missed treatment appointment and high attitude towards oral hygiene Exclusion Criteria: * Patients with relevant medical conditions that may affect periodontal regeneration and surgery * smokers, pregnant or lactating women * those whom periodontal surgery had previously been carried out on the selected site, * and patients who taking any drug known to affect the number or function of platelets

What they're measuring

probing pocket depth

Timeframe: 12 months

clinical attachment level

Timeframe: 12months

radiographic defect area by cone beam x ray

Timeframe: 12 months

radiographic bone density by cone beam

Timeframe: 12 months

Trial details

NCT IDNCT05001919

SponsorTanta University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-07-01

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