Endovenous Laser Ablation in Acute Thrombophlebitis of the Varicose Great Saphenous Vein

Inclusion Criteria: * Age 18 years or more * Acute thrombosis of varicose great saphenous vein and/or its major branches more than 5 cm from the saphenofemoral junction * Signed informed consent Exclusion Criteria: * More than 3 weeks after symptom onset * Ultrasound signs of deep vein thrombosis * Suspected pulmonary embolism * Superficial vein thrombosis within 5 cm from the saphenofemoral junction * Bilateral superficial vein thrombosis * Thrombosis of subfascial part of perforating veins to the level of fascia * Thrombosis of small saphenous vein * Superficial vein thrombosis associated with sclerotherapy * History of deep vein thrombosis and/or pulmonary embolism * Superficial vein thrombosis within 3 months before inclusion * Anemia (haemoglobin less than 90 g/l) * Low platelet count (less than 100 X 109/l) * Severe renal impairment (calculated GFR less than 20 ml/min/1,73 m2) * Body mass less than 50 kg * Morbid obesity (BMI higher than 40 kg/m2) * Allergy to fondaparinux sodium and local anaesthetics * Using anticoagulants for treating the current episode of venous thrombosis * Using anticoagulants for other medical conditions (e.g. atrial fibrillation) * Double antiplatelet therapy * Regular use of NSAIDs (except aspirin less than 325 mg daily) * High risk of bleeding according to an investigator * Active clinically relevant bleeding * Clinically relevant bleeding within last 30 days before inclusion * Major surgery of severe head trauma within last 30 days before…