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Association Between the Brain Excitability and Postoperative Delirium in Patients Undergoing Heart Valve Replacement Surgery With Cardiopulmonary Bypass

China90 participantsStarted 2020-07-01

Plain-language summary

The purpose of this study is to explorethe brain excitability in patients undergoing heart valve replacement surgery with cardiopulmonary bypass and the correlation with postoperative delirium

Who can participate

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. ASA Ⅱ - Ⅲ;
✓. No cognitive impairment was assessed one day before surgery;
✓. Patients undergoing elective heart valve replacement under CPB and signed informed consent.

Exclusion criteria

✕. Non-CPB surgery, macrovascular surgery, heart transplantation, correction of congenital heart disease;
✕. Stroke, schizophrenia, depression, Parkinson's disease, epilepsy or dementia;
✕. Inability to communicate with language impairment or major hearing or visual impairment;
✕. Liver function child-pugh Grade C, severe liver dysfunction;
✕. Severe renal insufficiency requires preoperative renal replacement therapy;
✕. A past history of intraoperative knowledge.

What they're measuring

The incidence of delirium after cardiac surgery

Timeframe: The first day after surgery

The incidence of delirium after cardiac surgery

Timeframe: The second day after surgery

The incidence of delirium after cardiac surgery

Timeframe: The third day after surgery

Abnormal EEG during surgery

Timeframe: Complete EEG information from entry to exit of the operating room

Plasma excitatory amino acid levels

Timeframe: Before the operation after entering the operating room (baseline)

Plasma excitatory amino acid levels

Timeframe: Immediately after surgery

Plasma excitatory amino acid levels

Timeframe: 24 hours after surgery

Trial details

NCT IDNCT05001425

SponsorGeneral Hospital of Ningxia Medical University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-12-01

Contact for this trial

Xinli Ni, doctor

86-951-674-3252 xinlini6@nyfy.com.cn

View on ClinicalTrials.gov More Brain Excitability trials

Who can participate

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. ASA Ⅱ - Ⅲ;
✓. No cognitive impairment was assessed one day before surgery;
✓. Patients undergoing elective heart valve replacement under CPB and signed informed consent.

Exclusion criteria

✕. Non-CPB surgery, macrovascular surgery, heart transplantation, correction of congenital heart disease;
✕. Stroke, schizophrenia, depression, Parkinson's disease, epilepsy or dementia;
✕. Inability to communicate with language impairment or major hearing or visual impairment;
✕. Liver function child-pugh Grade C, severe liver dysfunction;
✕. Severe renal insufficiency requires preoperative renal replacement therapy;
✕. A past history of intraoperative knowledge.

What they're measuring

The incidence of delirium after cardiac surgery

Timeframe: The first day after surgery

The incidence of delirium after cardiac surgery

Timeframe: The second day after surgery

The incidence of delirium after cardiac surgery

Timeframe: The third day after surgery

Abnormal EEG during surgery

Timeframe: Complete EEG information from entry to exit of the operating room

Plasma excitatory amino acid levels

Timeframe: Before the operation after entering the operating room (baseline)

Plasma excitatory amino acid levels

Timeframe: Immediately after surgery

Plasma excitatory amino acid levels

Timeframe: 24 hours after surgery