CompletedNot Applicable

Intrauterine Infusion of GCSF and Reproductive Outcomes in Infertile Women with History of RIF

Egypt100 participantsStarted 2019-09-01

Plain-language summary

Intrauterine infusion of granulocyte colony stimulating factor and reproductive outcomes in infertile women with history of recurrent implantation failure

Who can participate

Age range18 Years – 38 Years

SexFEMALE

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Inclusion criteria

✓. Age group (18-38)
✓. History of at least 2 previous IVF or ICSI trial failures with ET of at least 2 good quality embryos in each trial.
✓. Endometrial cavity within normal anatomy as assessed with transvaginal ultrasound (TV-US) with or without hysteroscopy and HSG if needed.
✓. Availability of good quality embryos (at least 2 grade A embryos) for ET in the investigated trial

Exclusion criteria

✕. Severe male factor infertility
✕. Poor ovarian reserve (according to ESHRE criteria) 1
✕. Uterine anatomic factor (eg polyp, intramural fibroid, endometrial septum, intrauterine synechiae .. etc) as well as endometritis
✕. Immunological disorder (eg: SLE, APS, … etc)
✕. Thyroid or adrenal dysfunction
✕. Thrombophilia history or tendency as proven by labs in suspected women
✕. Untreated hyperprolactinemia
✕. Genetic abnormalities in the infertile couple

What they're measuring

Clinical pregnancy rate

Timeframe: 4 weeks after ET

Trial details

NCT IDNCT04998279

SponsorCairo University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-08-30

View on ClinicalTrials.gov More Recurrent Implantation Failure trials