Axitinib + Ipilimumab in Advanced Melanoma

Inclusion Criteria: * Diagnosis of advanced/unresectable melanoma - uveal melanoma is excluded * Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2 * Adequate bone marrow, organ function and laboratory parameters as defined in protocol. * Patients must have adequately controlled blood pressure (\<150 systolic and \<100 diastolic) * At least 1 measurable lesion - per irRECIST 1.1 criteria * Documented disease refractory or intolerant to anti-PD-1/PD-L1 inhibitor treatment: in the metastatic setting or in the adjuvant setting if relapse on or within 6 months from end of anti-PD-1 treatment * If BRAFV600-mutant melanoma, patients may have had prior BRAF/MEK inhibitor therapy, or intolerance to these drugs * No limit to prior lines of treatment but prior ipilimumab not permitted * Prior treatment-related toxicity resolved to ≤ Grade 2 or baseline * Participants with a prior or concurrent malignancy whose natural history or treatment (in the opinion of the treating physician) does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial. * Prior to first dose of study treatment, patients must be at least 2 weeks from any prior major surgery. * Able to undergo a pre-treatment and on-treatment tumor biopsy * Female participants of childbearing potential must have a negative serum or urine β-HCG test result. Female participants of childbearing potential and male participants must agree to use …