Effective OnabotulinumtoxinA Dose Response Study for Upper Facial Wrinkles

Inclusion Criteria: * Provision of signed and dated informed consent form * Stated willingness to comply with all study procedures and availability for the duration of the study * Male or female, aged 18-65 * In good general health as evidenced by medical history and exhibiting upper facial wrinkles on physical examination * Agreement to adhere to Lifestyle Considerations (see section 5.3) as appropriate throughout study duration Exclusion Criteria: * Current use of aminoglycosides, curare like agents, and muscle relaxants * Pregnancy or lactation * Known allergic reactions to components of the botox formulation and any of its ingredients * Treatment with another botox product for the face within 4 months * Infections/preexisting weakness at the proposed injection sites on physical examination * History of neuromuscular disorder, pre existing severe cardiovascular disease, compromised respiratory function, severe dysphagia * Pediatric population, patients older than 65 since the effect of botox in terms of duration and magnitude is highly variable in these age groups.