Impact of COVID-19 Vaccines on Cerebrovascular Health (NCT04992195) | Clinical Trial Compass
CompletedNot Applicable
Impact of COVID-19 Vaccines on Cerebrovascular Health
Hong Kong415 participantsStarted 2021-07-05
Plain-language summary
Safe and effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines may reduce the transmission of and achieve population immunity against the COVID-19 pandemic, which accounted for more than 3.75million deaths worldwide. With World Health Organization's (WHO) effort on ensuring equitable access to COVID-19 vaccines, vaccination rate may increase in the near future.
On the other hand, vaccination hesitancy has emerged as a major hindrance on the global vaccination campaigns in certain areas due to safety concerns, social factors, and public health policies. For instance, a recent survey conducted in Hong Kong showed a low vaccine acceptance rate of 37%. Long-term safety concerns and post-vaccination events relayed by the social media maybe reasons for vaccination hesitancy. Among which, cerebrovascular accidents (CVA) after vaccination were one of the most frequently reported post-vaccination events. These reports ranged from ischemic strokes in elderly patients with multiple cardiovascular co-morbidities, to hemorrhage strokes in otherwise "young-and-fit" adults. While many of these events were investigated by the COVID-19 immunization expert committee, an important premise to address the apprehension of CVA after vaccination is the provision of evidence-based information of the impact of COVID-19 vaccines on brain health.
In this prospective, longitudinal, observational study, we aim to elucidate the relationship between COVID-19 vaccines and cerebrovascular health in healthy citizens in a population-based cohort.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Exclusion criteria
. Citizens with clinically evident stroke or dementia prior to recruitment; or
. Citizens who are unable to provide an informed consent; or
. Citizen with contraindications to MRI brain, e.g., non-MRI compatible implants, claustrophobia, etc; or
. Citizens who had no baseline MRI brain assessment.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial looked at imaging markers of cerebrovascular health in relation to COVID-19 vaccines — given my history or risk of stroke or dementia, does the imaging data from this study tell us anything relevant about my situation?
2Since this trial has already completed, has your medical team seen any published results from it, and if so, did the brain imaging findings reveal any meaningful signals about stroke or blood clot risk connected to COVID-19 vaccination?
3The trial covered a wide range of conditions including ischemic stroke, Alzheimer's disease, and both arterial and venous blood clots — which of these categories most applies to my own diagnosis, and would the findings from this kind of imaging study be useful in guiding my care?
4Because this was a Phase NA observational or imaging-focused study rather than a treatment trial, does that mean the results are more about understanding risk patterns than testing a specific therapy, and how should I interpret that when thinking about my own treatment options?
5Given that this study is now completed and was focused on brain imaging markers, are there any follow-up trials or clinical recommendations that have come out of this research that I should be aware of before making decisions about vaccination or cerebrovascular management?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.