Specific miRNAs in Sepsis and Nephrotoxic Antibiotic Treatment (NCT04991376) | Clinical Trial Compass
CompletedNot Applicable
Specific miRNAs in Sepsis and Nephrotoxic Antibiotic Treatment
Czechia53 participantsStarted 2019-05-02
Plain-language summary
Critically ill patients are prone to develop acute kidney injury due to sepsis itself and by administration of potentially nephrotoxic antibiotic treatment (vancomycin or gentamicin). Blood-specific miRNA levels associated with renal tubular damage change in patients treated with vancomycin or gentamicin compared to septic patients treated with other antimicrobials.
Who can participate
Age range
18 Years – 95 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
\- Critically ill adult septic patients with or without acute kidney injury treated by antimicrobial therapy
Exclusion Criteria:
\- Patients in the chronic dialysis program, with stage 4 and 5 chronic kidney disease, or concomitantly treated with another potentially severe nephrotoxic medication (cisplatin, colistin) or combination vancomycin/gentamicin.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial was studying miRNAs as potential markers of kidney injury in people with sepsis being treated with antibiotics — could my doctor explain what miRNAs are and why tracking them over 7 days might matter for monitoring kidney health during my treatment?
2Since this trial has already been completed, is it worth asking my doctor whether the results have been published, and whether any findings about early warning signs of antibiotic-related kidney injury could be relevant to how my care is managed now?
3Because this study specifically looked at patients receiving nephrotoxic antibiotics — meaning antibiotics that can be hard on the kidneys — should I be asking my care team which antibiotics I'm receiving and whether my kidney function will be closely monitored during treatment?
4This trial focused on sepsis and septic shock alongside acute kidney injury, so could my doctor explain whether my current situation puts me at risk for kidney complications, and what signs or lab values they'll be watching for?
5Since this was an observational study measuring biomarkers rather than testing a new treatment, does my doctor know of any ongoing or upcoming trials that are actually testing new ways to prevent kidney injury in sepsis patients, in case that could be a relevant option to explore?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.