CompletedNot Applicable

Specific miRNAs in Sepsis and Nephrotoxic Antibiotic Treatment

Czechia53 participantsStarted 2019-05-02

Plain-language summary

Critically ill patients are prone to develop acute kidney injury due to sepsis itself and by administration of potentially nephrotoxic antibiotic treatment (vancomycin or gentamicin). Blood-specific miRNA levels associated with renal tubular damage change in patients treated with vancomycin or gentamicin compared to septic patients treated with other antimicrobials.

Who can participate

Age range18 Years – 95 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: \- Critically ill adult septic patients with or without acute kidney injury treated by antimicrobial therapy Exclusion Criteria: \- Patients in the chronic dialysis program, with stage 4 and 5 chronic kidney disease, or concomitantly treated with another potentially severe nephrotoxic medication (cisplatin, colistin) or combination vancomycin/gentamicin.

What they're measuring

miRNAs expression over 7 days of treatment

Timeframe: 7 days

Trial details

NCT IDNCT04991376

SponsorUniversity Hospital Ostrava

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-06-30

View on ClinicalTrials.gov More Sepsis trials