CompletedPhase 2

Spirulina Platensis for PPI Withdrawal

45 participantsStarted 2010-11

Plain-language summary

Background: Rebound acid hypersecretion after proton pump inhibitors (PPIs) discontinuation may be accompanied by dyspepsia. Aim: To assess whether Spirulina platensis, by its anti-inflammatory properties, could minimize rebound symptoms after PPIs withdrawal.

Who can participate

Age range18 Years – 70 Years

SexALL

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Inclusion Criteria: * Chronic use of any PPIs, either original brand or generic * Absence of conditions that contraindicate the cessation of PPIs, such as active or recent peptic ulcer, active or recent upper digestive bleeding, regular use of salicylates or non-steroidal anti-inflammatory drugs, moderate to severe reflux esophagitis, and sliding hiatal hernia greater than 3 cm * Formal agreement to participate Exclusion Criteria: * Uncompensated acute and chronic morbidities * Gastroesophageal surgery * Cognitive deficit

What they're measuring

Number of participants with dyspeptic symptoms

Timeframe: 60 days

Number of participants with typical GERD symptoms

Timeframe: 60 days

Trial details

NCT IDNCT04988347

SponsorUniversidade de Passo Fundo

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2012-02

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