RecruitingEarly Phase 1

GWICTIC: NAC Mechanistic Study in Gulf War Veterans

United States170 participantsStarted 2023-11-30

Plain-language summary

This mechanistic study will test if NAC affects chronic oxidative stress and depletion of antioxidants in GWI participants. Blood specimen collection and neuroimaging will be used to determine whether NAC affects serum glutathione (GSH) concentration and oxidative stress in the CNS when compared to placebo.

Who can participate

Age range47 Years – 70 Years

SexALL

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Inclusion criteria

✓. Allowance of normal illness of aging, such as hypertension and diabetes, if the conditions are treated and are in demonstrable stable and normal ranges at the time of screening and assessment.
✓. Allowance of stable comorbid conditions such as Post Traumatic Stress Disorder (PTSD), Major Depressive Disorder (MDD), and mild Traumatic Brain Injury (mTBI) that have not required hospitalization in the 2 years prior to recruitment. Severe TBI is excluded.

What they're measuring

Assess glutathione levels

Timeframe: Baseline to 8 weeks

Trial details

NCT IDNCT04987775

SponsorNova Southeastern University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-04

Contact for this trial

Nancy Klimas, MD

9542622855 nklimas@nova.edu

View on ClinicalTrials.gov More Gulf War Syndrome trials