Comparing a Direct Versus an Indirect Approach to Measuring the Portalsytemic Pressure Gradients

Inclusion Criteria: * Patients with cirrhosis who have been referred for a procedure where HVPG is obtained. Exclusion Criteria: * Patient is pregnant, breast-feeding, or planning to become pregnant during the course of the study * Patient is unwilling or unable to sign and date the informed consent * Patient is unwilling to comply with the follow-up study schedule * Previous total or partial splenectomy * Non-cirrhotic portal hypertension * Known history of spontaneous bacterial peritonitis (SBP) within the last three months irrespective of treatment for SBP * Patients with known infection which is not controlled by medical intervention * Portopulmonary hypertension * Cardiac decompensation * Pre-sinusoidal liver disease * Cholestatic liver disease * Patient who received endoscopic treatment for upper gastrointestinal (GI) variceal bleeding within the past 7 days * Patients with current hepatocellular carcinoma (HCC)