Fractional Excretion of Urea for the Differential Diagnosis of Acute Kidney Injury in Cirrhosis

Inclusion Criteria: * Age greater than 18 years. * Decompensated liver cirrhosis (Child-Pugh classification B or more) of any etiology diagnosed by clinical parameters involving laboratory tests, endoscopic or radiologic evidence of cirrhosis, history of decompensation (hepatic encephalopathy, ascites, variceal bleeding, jaundice), and liver biopsy if available. * Use of either loop diuretics and/or distal diuretics (ex; spironolactone and eplerenone) until the time of admission. * Availability of a baseline serum creatinine as defined by the International Club Ascites. Exclusion Criteria: * Prior liver or kidney transplant * Advanced chronic kidney disease defined as serum creatinine greater than 4 mg/dL * Patients on acute or chronic renal replacement therapy * Patients with hepatocellular carcinoma.