Evaluate the Efficacy and Safety of MUSK Pill on Coronary Microvascular Dysfunction (NCT04984954) | Clinical Trial Compass
UnknownPhase 4
Evaluate the Efficacy and Safety of MUSK Pill on Coronary Microvascular Dysfunction
China264 participantsStarted 2021-01-28
Plain-language summary
Objective to evaluate the effect of Shexiang Baoxin Pill on myocardial ischemia in patients with coronary microvascular dysfunction (non obstructive coronary heart disease) through a randomized, double-blind, placebo-controlled clinical multicenter study.At the same time, the effects of exercise tolerance and quality of life were also observed.
Who can participate
Age range18 Years – 80 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Patients aged 18-80, male or female;
✓. Selective coronary angiography or coronary CTA showed that the diameter of coronary artery ≥ 2.5mm, the degree of stenosis \< 50%, without myocardial bridge;
✓. They were able to perform treadmill exercise, and the treadmill test (EET) was positive;
✓. Angina pectoris was found;
✓. Patients are willing to follow up and sign informed consent; All the above criteria should be met.
Exclusion criteria
✕. Coronary heart disease complicated with hypertrophic cardiomyopathy;
✕. There was a history of AMI, PCI and CABG, and myocardial bridge was found by angiography or CTA;
✕. Patients with severe medical diseases (liver, kidney, hematopoietic system and other serious primary diseases, etc.);
✕. Mental disorders and mental diseases;
✕. Patients with pulmonary failure and NYHA heart function grade III-IV, unable to carry out exercise test;
✕. Contraindications of Shexiang Baoxin Pill: forbidden for pregnant women;
✕. Those who have known history of allergy to Shexiang Baoxin Pills;
✕
What they're measuring
1
the difference of HRR between the experimental group and the placebo group was significant
Timeframe: At the end of treatment (8 weeks (± 1 week))
. Recently, the patient has taken Shexiang Baoxin Pill and other anti ischemic traditional Chinese medicine regularly, or it contains borneol, toad venom and other ingredients in Shexiang Baoxin Pill;