Evaluate the Efficacy and Safety of MUSK Pill on Coronary Microvascular Dysfunction (NCT04984954) | Clinical Trial Compass
UnknownPhase 4
Evaluate the Efficacy and Safety of MUSK Pill on Coronary Microvascular Dysfunction
China264 participantsStarted 2021-01-28
Plain-language summary
Objective to evaluate the effect of Shexiang Baoxin Pill on myocardial ischemia in patients with coronary microvascular dysfunction (non obstructive coronary heart disease) through a randomized, double-blind, placebo-controlled clinical multicenter study.At the same time, the effects of exercise tolerance and quality of life were also observed.
Who can participate
Age range
18 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Patients aged 18-80, male or female;
. Selective coronary angiography or coronary CTA showed that the diameter of coronary artery ≥ 2.5mm, the degree of stenosis \< 50%, without myocardial bridge;
. They were able to perform treadmill exercise, and the treadmill test (EET) was positive;
. Angina pectoris was found;
. Patients are willing to follow up and sign informed consent; All the above criteria should be met.
Exclusion criteria
. Coronary heart disease complicated with hypertrophic cardiomyopathy;
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
the difference of HRR between the experimental group and the placebo group was significant
Timeframe: At the end of treatment (8 weeks (± 1 week))
. There was a history of AMI, PCI and CABG, and myocardial bridge was found by angiography or CTA;
. Patients with severe medical diseases (liver, kidney, hematopoietic system and other serious primary diseases, etc.);
. Mental disorders and mental diseases;
. Patients with pulmonary failure and NYHA heart function grade III-IV, unable to carry out exercise test;
. Contraindications of Shexiang Baoxin Pill: forbidden for pregnant women;
. Those who have known history of allergy to Shexiang Baoxin Pills;
. Recently, the patient has taken Shexiang Baoxin Pill and other anti ischemic traditional Chinese medicine regularly, or it contains borneol, toad venom and other ingredients in Shexiang Baoxin Pill;