SuspendedNot Applicable

Assessment of Kidney Function and Osteomuscular Status After Critical Care

Stopped: Enrollment difficulties

Belgium100 participantsStarted 2023-03-01

Plain-language summary

This observational study aims to assess kidney function through direct glomerular filtration rate (GFR) using iohexol clearance, compared to estimated GFR based on creatinine and cystatin C equations. Kidney function will also be evaluated through renal fibrosis biomarkers. Kidney function will be correlated to body composition, muscle turnover biomarkers, and bone micro-architecture.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * patients surviving an ICU stay of at least 7 days * patients who experienced acute kidney injury (KDIGO criteria) during ICU stay Exclusion Criteria: * chronic kidney injury with dedicated follow-up before ICU admission * chronic extrarenal epuration * kidney transplant * allergy to iohexol * iodinated contrast allergy * refusal

What they're measuring

measured GFR

Timeframe: between day 0 and day 7 after ICU discharge

measured GFR

Timeframe: at 3 months after ICU discharge

measured GFR

Timeframe: at 12 months after ICU discharge

estimated GFR

Timeframe: between day 0 and day 7 after ICU discharge

estimated GFR

Timeframe: at 3 months after ICU discharge

estimated GFR

Timeframe: at 12 months after ICU discharge

Trial details

NCT IDNCT04980092

SponsorUniversity of Liege

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-03

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