Gum Arabic ingestion has been proved to decrease some of the inflammatory markers in some metabolic diseases that have an inflammatory background. Nevertheless, the mechanism/s by which it does so is uncertain. This study is targeting one of the postulated molecular mechanisms at genetic level that may help to understand how Gum Arabic exerts its effect .The effects of GA on Nuclear Factor Kappa Beta, P38 Mitogen Activated Protein (MAP) Kinase levels, and on the expression of inflammatory cytokines genes are going to be assessed in postmenopausal females with Metabolic Syndrome.
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Nuclear Factor Kappa Beta concentration in nanogram/dl
Timeframe: 12 weeks
P38 Mitogen activated protein kinase in nanogram/dl
Timeframe: 12 weeks
Inhibitory Kappa Beta protein in nanogram/dl
Timeframe: 12 weeks
Tumor necrosis factor, interferon gamma and interleukin-6 in nanogram/dl
Timeframe: 12 weeks
Plasminogen activated protein inhibitor1 in picogram/dl
Timeframe: 12 weeks
Fasting Insulin in nanogram/dl
Timeframe: 12 weeks
Insulin resistance by HOMA index
Timeframe: 12 weeks