Multiple sclerosis (MS) is an inflammatory autoimmune disease associated with an imbalance between pro- and anti-inflammatory markers (cytokines) resulting in a demyelinating and neurodegenerative disease. There is early evidence that spinal manipulation (chiropractic care) is better than control in influencing immune (cytokine) activity in asymptomatic participants, but few studies have been completed in participants with chronic inflammatory conditions, such as MS. The purpose of this project is to examine the immediate (after a single thoracic spinal manipulation treatment) and summative impact (after 8 thoracic spinal manipulation treatments occurring over 4 weeks) on pro-inflammatory (interleukin (IL) IL-1ß, IL-2, IL-6, Tumor necrosis factor-alpha) and anti-inflammatory (IL-4, IL-10) plasma cytokines 20 minutes and 2 hours after thoracic spinal manipulation in participants diagnosed with neuroinflammatory relapsing-remitting MS (RR-MS). Spinal manipulation treatment will be limited to the thoracic spine. Secondary outcomes will include determining the impact of 8 thoracic spinal manipulations on fatigue, cognitive processing speed, pain, depression, sleep, and motor function through questionnaires and performance of various in assessments such as the timed 25 foot walk test.
Age range
18 Years – 55 Years
Sex
ALL
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The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
IL-6 Serum Inflammatory Cytokine Levels
Timeframe: From baseline to after 8th treatment at 4 weeks
IL-4 Serum Inflammatory Cytokine Levels
Timeframe: From baseline to after 8th treatment at 4 weeks
IL-10 Serum Inflammatory Cytokine Levels
Timeframe: From baseline to after 8th treatment at 4 weeks
IL-2 Serum Inflammatory Cytokine Levels
Timeframe: From baseline to after 8th treatment at 4 weeks
TNFalpha Serum Inflammatory Cytokine
Timeframe: baseline to after 8th treatment at 4 weeks
IL-B Serum Cytokine Levels
Timeframe: baseline and 8th treatment after 4 weeks