Impact of Malnutrition on Pharmacokinetic of Rifampicin, Isoniazid, Pyrazinamide and Ethambutol in TB-HIV Co-infected Children (TB-Speed TB-PK)

INCLUSION CRITERIA: * Gr1. HIV-infected children with SAM * Age 6 months to 5 years * Diagnosed with TB and first line TB treatment to be initiated or started less than 4 weeks prior to inclusion * HIV-infection * SAM as defined by WHO at the time of starting TB treatment * Weight-for-height z-score (WHZ) \< -3 SD, * OR MUAC \<11.5 cm or * OR presence of bilateral pitting oedema of nutritional origin * Ability to take drugs orally during the planned PK day * Signed informed consent from parents or guardian * Gr2. HIV-infected children without SAM * Age 6 months to 5 years * Diagnosed with TB and first line TB treatment to be initiated or started less than 4 weeks prior to inclusion * HIV-infection * Absence of SAM as defined by WHO at the time of starting TB treatment * Weight-for-height z-score (WHZ) \> -3 SD, * AND MUAC \>11.5 cm or * AND absence of bilateral pitting oedema of nutritional origin * Ability to take drugs orally during the planned PK day * Signed informed consent from parents or guardian * Gr3. HIV-negative children with SAM * Age 6 months to 5 years * Diagnosed with TB and first line TB treatment to be initiated or started less than 4 weeks prior to inclusion * HIV-negative * SAM as defined by WHO at the time of starting TB treatment * Weight-for-height z-score (WHZ) \< -3 SD, * OR MUAC \<11.5 cm or * OR presence of bilateral pitting oedema of nutritional origin * Ability to take drugs orally during the …