The gender, age, ICU diagnosis, basic diseases, antibiotic treatment plan, physiological indicators, duration of hospital stay, length of stay in ICU, hospitalization cost, prognosis and other discharge information of patients receiving tigecycline or polymyxin B admitted to the ICU of four provincial-level Grade A hospitals in Changsha, Hunan Province ,China from 2017 to 2021 were included. To analyze the therapeutic effect of tigecycline-based or polymyxin B-based antibiotic regimens and their effect on the prognosis of patients, and to conduct subgroup analysis.
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hospital mortality rate
Timeframe: up to hospital discharge or die in hospital, up to 48 weeks(estimation).
30d mortality rate
Timeframe: up to the 30th day of the treatment of tigecycline or polymyxin B
Bacterial clearance rate
Timeframe: from the first day of the treatment of tigecycline or polymyxin B until to the end day, up to 8 weeks (estimation).