The purpose of this prospective study is to analyze function and phenotype of blood neutrophils in cystic fibrosis patients and the impact of Pseudomonas aeruginosa chronic infection, treatment with CFTR modulators and acute exacerbation on blood neutrophils phenotype and function.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patient over the age of 18 who is not under legal protection
* Patients with CF according to the diagnostic criteria of the Cystic Fibrosis Foundation including:
* 15 patients with severe mutation but not chronically infected with PA and not treated with lumacaftor / ivacaftor
* 15 patients homozygous phe508del, chronically infected with PA and not treated with lumacaftor / ivacaftor
* 15 patients homozygous phe508del, chronically infected with PA and treated with lumacaftor / ivacaftor
* 15 hospitalized patients for respiratory exacerbation
* 40 patients initiating Ivacaftor-Tezacaftor-Elexacaftor treatment.
* No change in baseline treatment for 15 days (including antibiotic treatment).
* Patient affiliated to a social security system
* Free, informed and written consent, dated and signed by the patient and the investigator, at the latest on the day of inclusion and before any action required by the study.
Exclusion Criteria:
* Informed consent impossible to obtain
* Involvement in an interventional research protocol in the previous 3 months if exclusion directive was given in this protocol.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Quantification of blood low density neutrophils in cystic fibrosis (CF)
Timeframe: Through study completion, an average of 1 year
2
Transcriptomic analysis of blood neutrophils in cystic fibrosis (CF)
Timeframe: Through study completion, an average of 1 year
3
Effector function analysis of blood neutrophils in CF.
Timeframe: Through study completion, an average of 1 year
4
Phagocytosis potential of blood neutrophils in CF.
Timeframe: Through study completion, an average of 1 year
5
Survival/apoptosis balance analysis in CF
Timeframe: Through study completion, an average of 1 year