HFpEF and Symptomatic Obstructive Iliofemoral Venous Disease Study

Inclusion Criteria: * Willing and able to provide informed consent and comply with all study requirements * Age ≥ 40 years of age * Stable, symptomatic heart failure with preserved ejection fraction and a H2FpEF Score ≥4 * Presence of non-malignant inferior vena cava obstruction, a unilateral or bilateral chronic non-malignant obstruction of the common femoral vein, external iliac vein, common iliac vein, or any combination thereof, defined as a ≥50% reduction in target vessel lumen diameter defined by screening MRV, CTV and confirmed by a 50% reduction in luminal area as assessed by intraprocedural IVUS. * Previous (\>6 months) history of ilio-femoral and/or lower extremity deep venous thrombosis associated with a residual ilio-femoral venous obstruction ≥50% by MRV, CTV. * Clinically significant venous obstruction meeting CEAP Clinical classification ≥3. * Negative pregnancy test in females of child-bearing potential Exclusion Criteria: * Subject hospitalized for acute compensated heart failure within 60 days prior to enrollment * Presence of history of clinically significant pulmonary emboli within 6 months prior to enrollment. * Subject has any permanent neurologic defect that may cause non-compliance with the protocol * Subject has known life-limiting immunosuppressive or autoimmune disease (e.g., human immunodeficiency virus, systemic lupus erythematous). * Subject has an allergy to contrast media that cannot be adequately pre-treated prior to the required diagnostic…