In patients with Chronic Kidney Disease (CKD), there is a buildup of nitrogenous uremic toxins of gut microbiome origin, which can contribute to uremic symptoms, reduced quality of life, and earlier progression to dialysis. The goal of this project is to investigate whether the consumption of resistant potato starch (RPS) as an adjunctive therapy to current standard of CKD care will reduce uremic toxins and symptoms by altering the gut microbiota in patients with CKD.
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Change in blood uremic toxin, indoxyl sulphate, between treatments
Timeframe: between endpoints of each experimental period (week 8 to week 18)
Change in blood uremic toxin, p-cresyl sulphate, between treatments
Timeframe: between endpoints of each experimental period (week 8 to week 18)