Retinoblastoma (RB) is a primary eye cancer that forms in the back of the eye of infants and toddlers. Traditionally, RB is diagnosed without a biopsy; tumor can only be studied once an eye has been surgically removed. Given this limitation, we use aqueous humor (AH), the clear fluid in the front of the eye to detect specific markers, or information, that comes from the tumor itself.
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Correlation of Ocular Salvage (eye saved) with biomarkers
Timeframe: through study completion, a minimum of 12 months after diagnosis and average of 24 months
Identification of RB1 (RB Transcriptional Corepressor 1) gene mutations from the AH liquid biopsy
Timeframe: through study completion, a minimum of 12 months after diagnosis and average of 24 months