RecruitingNot Applicable

Semantic Rehabilitation for Patients With Primary Progressive Semantic Aphasia

France15 participantsStarted 2021-09-20

Plain-language summary

This project aims to measure the effect of a semantic rehabilitation protocol for patients with primary progressive semantic aphasia and using the SCED methodology.

Who can participate

Age range

18 Years – 100 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Have a diagnosis of primary progressive semantic aphasia according to the criteria of Gorno-Tempini et al (2011) (Appendix A) * Being in the mild to moderate stage of dementia (MMSE score between 10 and 28) (Crum et al., 1993; Derouesné et al., 1999) * Common French * Being affiliated to a social security scheme * Being over the age of 18 years old Exclusion Criteria: * Have significant uncorrected visual and/or hearing impairment * Have a history of brain injuries, major head trauma * Have untreated psychiatric disorders * Have significant motor and/or comprehension problems that make it impossible to take part in the study * Chronical use of drugs and/or alcohol * Under guardians or curators * Severe depression (Beck's depression scale score \> 9) (Beck \& al., 1961)

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Performance in speaking

Timeframe: Baseline (before phase A)

Performance in speaking

Timeframe: Baseline (before phase A)

Performance in speaking

Timeframe: immediately after the intervention (after phase B)

Performance in speaking

Timeframe: immediately after the intervention (after phase B)

Trial details

NCT IDNCT04957537

SponsorUniversity Hospital, Toulouse

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-03-20

Contact for this trial

Jérémie PARIENTE, MD PhD

0561777686 pariente.j@chu-toulouse.fr

View on ClinicalTrials.gov More Primary Progressive Aphasia trials

Who can participate

Age range

18 Years – 100 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.