CompletedNot Applicable

Screening of Specific Genes for Pigmented Villous Nodular Synovitis

China60 participantsStarted 2020-08-03

Plain-language summary

This study retrospectively analyzed the history of present illness of PVNS patients in our hospital. The enrolled patients were followed up by telephone to follow up their postoperative recovery and living conditions. Take the patient's pathological specimens for immunohistochemical testing, evaluate the relationship between the expression of different molecular targets, clinical manifestations and patient prognosis, and explore new molecular targets related to disease diagnosis and treatment.

Who can participate

Age range

18 Years – 60 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Clinical diagnosis of pigmented villonodular synovitis.
. Clinical diagnosis of giant cell tumor of tendon sheath

Exclusion criteria

. No surgical treatment.
. There were no pathological specimens during the operation.
. The age of the patient is less than 18 years old or more than 60 years old.
. The operation record shows nodular type.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Difference of scale score between immunohistochemistry positive group and negative group

Timeframe: One week after surgery

Difference of Visual Analog Score for pain between TNF-α immunohistochemistry positive group and negative group

Timeframe: One week after surgery

Difference of Visual Analog Score for pain between IL-1B immunohistochemistry positive group and negative group

Timeframe: One week after surgery

Difference of SF-36 score between CSF-1 immunohistochemistry positive group and negative group

Timeframe: One week after surgery

Difference of SF-36 score between TNF-α immunohistochemistry positive group and negative group

Timeframe: One week after surgery

Difference of SF-36 score between IL-1B immunohistochemistry positive group and negative group

Timeframe: One week after surgery

Trial details

NCT IDNCT04955535

SponsorPeking University Third Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2020-12-27

View on ClinicalTrials.gov More Pigmented Villonodular Synovitis trials

Plain-language summary

Who can participate

Age range

18 Years – 60 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Clinical diagnosis of pigmented villonodular synovitis.
. Clinical diagnosis of giant cell tumor of tendon sheath

Exclusion criteria

. No surgical treatment.
. There were no pathological specimens during the operation.
. The age of the patient is less than 18 years old or more than 60 years old.
. The operation record shows nodular type.

What they're measuring

Difference of scale score between immunohistochemistry positive group and negative group

Timeframe: One week after surgery

Difference of Visual Analog Score for pain between TNF-α immunohistochemistry positive group and negative group

Timeframe: One week after surgery

Difference of Visual Analog Score for pain between IL-1B immunohistochemistry positive group and negative group

Timeframe: One week after surgery

Difference of SF-36 score between CSF-1 immunohistochemistry positive group and negative group

Timeframe: One week after surgery

Difference of SF-36 score between TNF-α immunohistochemistry positive group and negative group

Timeframe: One week after surgery

Difference of SF-36 score between IL-1B immunohistochemistry positive group and negative group

Timeframe: One week after surgery