Thyroid Replacement Therapy in Patients With Subclinical Hypothyroidism (NCT04953195) | Clinical Trial Compass
UnknownPhase 4
Thyroid Replacement Therapy in Patients With Subclinical Hypothyroidism
China30 participantsStarted 2019-01-01
Plain-language summary
The purpose of this experiment is to compared the changes of thyroid function, anti-thyroid peroxidase antibody, anti-thyroglobulin antibody, thyroid magnetic resonance T1-mapping and various metabolic indexes from baseline to the end of treatment (after the thyroid function had been normal for more than three months)
Who can participate
Age range
18 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Men or women between the ages of 18 and 75;
* Diagnostic criteria for mild subclinical hypothyroidism :TSH\>10mIU/L, thyroxine and free thyroxine levels were normal
* Positive thyroglobulin antibody and/or Thyroperoxidase antibody
* No previous use of drugs affecting thyroid function
Exclusion Criteria:
* The contraindications indicated in the Chinese instructions of the drug
* Liver function impairment
* Renal function impairment
* Claustrophobia
* Mental disorders
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Thyroid Stimulating Hormone changes
Timeframe: Thyroid Stimulating Hormone Changes from baseline and 12 weeks during follow-up
2
free thyroxine changes
Timeframe: free thyroxine changes from baseline and 12 weeks during follow-up
3
T1-mapping values of Thyroid MRI
Timeframe: T1-mapping values of Thyroid MRI Changes from baseline and 12 weeks during follow-up
4
Free triiodothyronine changes
Timeframe: Free triiodothyronine changes Changes from baseline and 12 weeks during follow-up