CompletedNot Applicable

MTHFR Mutation and Concentration of B12,Folic Acid,Homocysteine and HS CRP in the Blood of Pregnant Women With GDM.

Bosnia and Herzegovina100 participantsStarted 2020-09-01

Plain-language summary

Research hypothesis: * pregnant women with gestational diabetes have elevated serum CRP values and homocysteine compared to pregnant women with normal glucose metabolism * Elevated CRP and homocysteine values are associated with poorer perinatal outcome. * reduced concentrations of folic acid and vitamin B 12 are associated with higher homocitein values * Carriers of the MTHFR gene mutation have higher homocysteine concentrations

Who can participate

Age range18 Years – 35 Years

SexFEMALE

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Inclusion Criteria: * age of respondents from 18 to 35 years * Single pregnancies BMI from 18.5 to 29.9 kg / m 2 Exclusion Criteria: * Diagnosis of acute and chronic inflammatory diseases * Pregestational diabetes * Chronic hypertension * Multiple pregnancies * Smoking

What they're measuring

Whether increased hs crp and homocysteine values are associated with poorer perinatal outcome

Timeframe: Between 24 and 28 weeks of gestation

carriers of the MTHFR gene mutation have higher serum homocysteine concentrations in the blood

Timeframe: Between 24 and 28 weeks of gestation

Trial details

NCT IDNCT04952324

SponsorUniversity of Mostar

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2022-12-31

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