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Systemic Nitrosative/Oxidative Stress in Patients with Acute Brain Injury

Denmark150 participantsStarted 2021-08-18

Plain-language summary

Acute brain injury due to traumatic brain injury (TBI), intracerebral haemorrhage (ICH), and aneurysmal subarachnoid haemorrhage (SAH) carries a high morbidity and mortality, in part due to the development of secondary brain injury. The mechanisms behind secondary brain injury are incompletely understood, but oxidative/nitrosative stress and disturbances in the metabolism of the vasodilator nitric oxide (NO) are believed to be involved. The aim of the present study is to characterise systemic changes in markers of oxidative/nitrosative stress and NO metabolism in the early phase after acute brain injury, and to examine their relationship to clinical course, neurological outcome, and mortality.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Admission to the Neurointensive Care Unit (NICU) at Rigshospitalet * Diagnosis of TBI, spontaneous ICH or aneurysmal SAH * Initiation of blood sampling possible within 3 days after ictus * Expected length of stay in the NICU and/or intermediate care unit of ≥48 hours * Closest relatives understand written and spoken Danish Exclusion Criteria: * Brain death before inclusion * Expected death within 24 hours * ICH secondary to other causes (e.g., a tumour or arteriovenous malformation) * SAH secondary to other causes (e.g., a mycotic aneurysm or arteriovenous malformation)

What they're measuring

Neurological outcome (modified Rankin scale)

Timeframe: 6 months

Trial details

NCT IDNCT04951453

SponsorRigshospitalet, Denmark

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-04-30

View on ClinicalTrials.gov More Subarachnoid Hemorrhage, Aneurysmal trials