UnknownNot Applicable

GNAO1 Natural History Study

United States50 participantsStarted 2019-02-18

Plain-language summary

The purpose of the GNAO1 Natural History Study is to establish the clinical phenotype of GNAO1 associated neurologic disease, its association with genotype, and areas of clinical importance within the disease.

Who can participate

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Enrollment in the Bow Foundation GNAO1 registry. * Evidence of a known pathogenic mutation in GNAO1 or a variant of unknown significance and clinical symptoms likely to be consistent with GNAO1 as determined by study physicians. Exclusion Criteria: * Inability to obtain informed consent from parents or adult subjects. * Inability to obtain medical records.

What they're measuring

Chorea

Timeframe: March 2019; May-Oct 2020

Dystonia

Timeframe: March 2019; May-Oct 2020

Gross motor development, mobility

Timeframe: March 2019; May-Oct 2020

Spasticity

Timeframe: March 2019

Fine motor development

Timeframe: March 2019

Quality of Life and Caregiver Burden

Timeframe: March 2019; May-Oct 2020

Trial details

NCT IDNCT04950946

SponsorWashington University School of Medicine

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2022-12

View on ClinicalTrials.gov More GNAO1 trials