CompletedNot Applicable

Glutamine Supplement in MELAS (Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like Episodes) Syndrome

Spain9 participantsStarted 2021-06-28

Plain-language summary

The purpose of this study is to assesses the efficacy of oral supplementation with glutamine over three months on several amino acids and lactate concentration measured in cerebrospinal fluid and cerebral lactate measured by magnetic resonance spectroscopy.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * The diagnosis of MELAS syndrome is based on medical history (lactic acidosis, stroke-like episodes, and encephalomyopathy). * Subjects have to be clinically stable for more than six months after any stroke-like episodes. * All subjects have to be genetically confirmed. Exclusion Criteria: * Subjects harboring a MELAS-related pathogenic mtDNA mutation, no fulfilling the complete diagnostic criteria for the MELAS phenotype.

What they're measuring

Amino Acids concentration in cerebrospinal fluid

Timeframe: 3 months

Lactate concentration in cerebrospinal fluid

Timeframe: 3 months

Trial details

NCT IDNCT04948138

SponsorJesús González de la Aleja Tejera

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-09-09

View on ClinicalTrials.gov More MELAS Syndrome trials