Relationship of Exercise, Sleep, and Inflammation Markers in People Living With HIV

Inclusion Criteria: * confirmed HIV infection * sedentary lifestyle, defined as self-reported physical activity that breaks a sweat \<3 days/week, with no regular resistance exercise for 3 months prior to the study * on a current, modern antiretroviral therapy (ART) (anti-retroviral regimen) * documented HIV-1 RNA \<200 copies/mL in the past 12 months * willing to engage in a supervised exercise program 3 times/week for 16 weeks * poor sleep quality based on self-report survey (Pittsburgh Sleep Quality Index, total score \>5) * aged ≥ 50 years * English speaking Exclusion Criteria: * not controlled hypertension-defined as resting systolic blood pressure \>150 mmHg or diastolic blood pressure \>90 mmHg; participants who do not meet these criteria at first screening will be re-evaluated, including follow-up evaluation by their primary care provider with initiation or adjustment of anti-hypertensive medications * Indicators of unstable ischemic heart disease (e.g., angina) or serious arrhythmias-at rest or during the graded exercise test without negative follow-up evaluation will be cause for exclusion; follow-up evaluation must include diagnostic testing (e.g., thallium stress test) with interpretation by a cardiologist * New York Heart Association Class III or IV congestive heart failure, clinically significant aortic stenosis, uncontrolled angina, or uncontrolled arrhythmia * Pulmonary disease-requiring the use of supplemental oxygen at rest or with physical exertion