The proposed research will test the hypothesis that objective social isolation and loneliness are linked to neurobehavioral mechanisms involved in social perception and motivation in individuals with and without serious mental illness. Moreover, it will investigate the specific dynamic interactions among these experiences in daily life and how they, and their neurobehavioral predictors, are linked to day-to-day functioning. The findings of this project could provide novel targets for therapeutics aimed at improving functioning and overall quality of life in individuals with serious mental illnesses, as well as quantitative phenotypes for use in early detection efforts.
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Trait level social isolation and loneliness
Timeframe: 6 months
Characterize within-person, dynamic changes in objective isolation and loneliness
Timeframe: 6 months
Psychosocial functioning
Timeframe: 6 months
Physical health and cardiometabolic/immunological panel
Timeframe: 6 months