Epidural Analgesia and Maternal Fever During Labor (NCT04940091) | Clinical Trial Compass
CompletedNot Applicable
Epidural Analgesia and Maternal Fever During Labor
China1,051 participantsStarted 2021-06-10
Plain-language summary
Women who receive epidural analgesia during labor are more likely to develop fever than those who do not. Maternal fever during labor can produce various harmful effects on both mothers and infants. The investigators speculate that the effect of epidural analgesia is associated with the development of maternal fever, i.e., better analgesia is associated with higher risk of maternal fever.
Who can participate
Age range18 Years
SexFEMALE
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Inclusion Criteria:
* Age ≥18 years old;
* Nulliparae with single term cephalic pregnancy;
* Preparing to give vaginal delivery under epidural analgesia.
Exclusion Criteria:
* Basal body temperature ≥37.3°C;
* Presence of serious pregnancy complications (such as severe preeclampsia, placenta accreta, HELLP \[Hemolysis, Elevated Liver enzymes, Low Platelet count\] syndrome, placenta previa, abruption of placenta, or hyperthyroidism);
* History of hyperthyrodism, including hyperthyrodism in pregnancy;
* Taking sedatives and/or analgesics within one week before planned delivery;
* American Society of Anesthesiologists classification \>class III;
* Contraindications to epidural puncture, including central nervous system diseases (such as poliomyelitis), spinal diseases (such as intraspinal mass, lumbar disc herniation, history of spinal trauma, etc.), abnormal blood coagulation, etc.;
* Presence of infections, including obstetric infections, systemic infections (such as sepsis, bacteremia), or infections at the puncture site or adjacent sites;
* Other conditions that are considered unsuitable for study participation;
* Refused to participate in the study.