CompletedNot Applicable

Airborne Preventive Measures to Reduce New TB Infections in Household Contacts

Chile432 participantsStarted 2021-10-04

Plain-language summary

Tuberculosis (TB) is currently one of the top 10 causes of death worldwide and the leading cause of death from a single infectious agent (ranking above HIV/AIDS). The investigators hypothesize that reducing respiratory exposure within the household, during the first weeks of TB treatment initiation of the index case, can reduce new TB infections in close contacts. For this purpose, a pilot, controlled, pre-post study will be set up, to evaluate the feasibility of implementing a bundle of respiratory precautions to all household contacts of new pulmonary TB cases, compared to standard of care, in primary health care in a high TB incidence area in Santiago, Chile.

Who can participate

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * all household contacts of a new case of pulmonary TB (smear, culture or PCR positive) newly diagnosed at each clinic. Exclusion Criteria: * household contacts found to have co-prevalent active TB at enrolment * household contacts planning to leave the house at the time of enrolment * household contacts of index cases having already initiated TB treatment for \> 48h * household contacts of index cases that are currently hospitalized

What they're measuring

Participation rate

Timeframe: 2 weeks

Study compliance

Timeframe: 2 weeks

Completion rate

Timeframe: 12 weeks

Acceptability of the intervention

Timeframe: 12 weeks

Trial details

NCT IDNCT04938596

SponsorPontificia Universidad Catolica de Chile

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-03-30

View on ClinicalTrials.gov More Tuberculosis, Pulmonary trials