The pilot study proposal aims to modulate craving and attentional bias towards smoking cues in 40 people living with HIV/AIDS (PLWHA) using transcranial magnetic stimulation (TMS), with functional MRI (fMRI) brain correlates. TMS is a form of noninvasive brain stimulation and modulates neural activity using tiny doses of focused electricity. For the study, participants would perform two cognitive tasks and neuroimaging before and after the TMS and investigators would compare changes in these paradigms with TMS. The investigators will also get a point of contact urine drug screen before study initiation. The investigators will aim to recruit 20 subjects in each arm of our trial (total of 40) from the BlueGrass HIV Clinic.
Age range
18 Years – 60 Years
Sex
ALL
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The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Change in Attentional Bias iTBS (Intermittent Theta Burst Stimulation) Smoking
Timeframe: baseline and immediately after intervention, approximately 4 hours
Change in Attentional Bias Sham Smoking
Timeframe: baseline and immediately after intervention, approximately 4 hours
Change in Attentional Bias iTBS Paraphernalia
Timeframe: baseline and immediately after intervention, approximately 4 hours
Change in Attentional Bias Sham Paraphernalia
Timeframe: baseline and immediately after intervention, approximately 4 hours