The pilot study proposal aims to modulate craving and attentional bias towards smoking cues in 40 people living with HIV/AIDS (PLWHA) using transcranial magnetic stimulation (TMS), with functional MRI (fMRI) brain correlates. TMS is a form of noninvasive brain stimulation and modulates neural activity using tiny doses of focused electricity. For the study, participants would perform two cognitive tasks and neuroimaging before and after the TMS and investigators would compare changes in these paradigms with TMS. The investigators will also get a point of contact urine drug screen before study initiation. The investigators will aim to recruit 20 subjects in each arm of our trial (total of 40) from the BlueGrass HIV Clinic.
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Change in Attentional Bias iTBS (Intermittent Theta Burst Stimulation) Smoking
Timeframe: baseline and immediately after intervention, approximately 4 hours
Change in Attentional Bias Sham Smoking
Timeframe: baseline and immediately after intervention, approximately 4 hours
Change in Attentional Bias iTBS Paraphernalia
Timeframe: baseline and immediately after intervention, approximately 4 hours
Change in Attentional Bias Sham Paraphernalia
Timeframe: baseline and immediately after intervention, approximately 4 hours