CompletedNot Applicable

Study on the Effect of Capacity Shock Intervention Under Goal-directed Hemodynamic Management on P-V Loop

China20 participantsStarted 2020-06-01

Plain-language summary

By observing the changes of P-V loop in capacity shock intervention Under Goal-directed Hemodynamic Management in patients undergoing total knee replacement, we investigate the effect of capacity shock on cardiac contractility and work in order to seek a more effective target plan of capacity shock for intraoperative patients.

Who can participate

Age range

40 Years – 70 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: ASAI-II age 40- 70 weight 48 - 72 kg. Exclusion Criteria: Body mass index \>30 or \<15 kg/m2 Valve heart disease Left ventricular ejection fraction (LVEF) is less than 50% History of lung disease Preoperative arrhythmic disorder Permanent pacemaker Need for mechanical heart Support, Severe extrinsic vascular disease Valve dysfunction OED monitoring probe insertion contraindications Patients with preoperative assessments

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Ees

Timeframe: Baseline，After induction

Ees

Timeframe: Immediately after the intervention,complete of the first round of the fluid challenge

Ees

Timeframe: Immediately after the intervention,complete of the second round of the fluid challenge

Ees

Timeframe: 1h after the first fluid challenge

Ees

Timeframe: At the end of surgery

Timeframe: Baseline，after induction

Timeframe: Immediately after the intervention,complete of the first round of the fluid challenge

Timeframe: Immediately after the intervention,complete of the second round of the fluid challenge

Trial details

NCT IDNCT04934761

SponsorGuangzhou Red Cross Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-05-01

View on ClinicalTrials.gov More Hemodynamics trials

Plain-language summary

Who can participate

Age range

40 Years – 70 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Ees

Timeframe: Baseline，After induction

Ees

Timeframe: Immediately after the intervention,complete of the first round of the fluid challenge

Ees

Timeframe: Immediately after the intervention,complete of the second round of the fluid challenge

Ees

Timeframe: 1h after the first fluid challenge

Ees

Timeframe: At the end of surgery

Timeframe: Baseline，after induction

Timeframe: Immediately after the intervention,complete of the first round of the fluid challenge

Timeframe: Immediately after the intervention,complete of the second round of the fluid challenge