Cerebral Autoregulation and COVID-19

Inclusion Criteria: * Admission to ICU and endotracheal intubation/mechanical ventilation for severe COVID-19 infection Exclusion Criteria: * Age \<18 years * Pregnancy * Patients with a terminal underlying disease who are unlikely to survive until discharge from the hospital * Patients with acquired immunodeficiency and ("pre-COVID") lymphocyte Cluster Differentiation 4+ count \<50 / μL * Patients with COVID-19 who have been transferred from another hospital * Patients with a history of allergic reaction * Use of prone position to facilitate mechanical ventilation * Absence of signed informed consent from a first degree relative