Active — Not RecruitingNot Applicable

Carbon-13 Magnetic Resonance Spectroscopy in Glycogen Storage Diseases

Denmark50 participantsStarted 2021-12-10

Plain-language summary

The project will use carbon-13 magnetic resonance spectroscopy to assess whether high glycogen levels in skeletal muscle of patients with Glycogen Storage Diseases is a prelude for muscle damage. Patients with Glycogen Storage Diseases will be examined using carbon-13 MR-spectroscopy to quantify the glycogen levels in lumbar, thigh and calf-muscles. The pattern of glycogen concentration will be compared to the pattern of muscle atrophy found in the literature.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Subjects with genetically verified neuromuscular disease or healthy control * Healthy controls needs to be healthy to be included, evaluated by the investigator Exclusion Criteria: * Ferrous objects in or around the body * Pacemaker or other implanted electronic devices * Claustrophobia * Inability to understand the purpose of the trial or corporate for the conduction of the experiments. * Participation in other trials that may interfere with the results. * Competing conditions at risk of compromising the results of the study, evaluated by the investigator. * Strenuous exercise in the preceding 2 days before examination * Pregnancy or breastfeeding

What they're measuring

Glycogen concentration

Timeframe: Day 1

Trial details

NCT IDNCT04929002

SponsorRigshospitalet, Denmark

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2028-05

View on ClinicalTrials.gov More Glycogen Storage Disease trials