UnknownNot Applicable

Single-cell Sequencing and Establishment of Models in Neuroendocrine Neoplasm

China200 participantsStarted 2021-06-06

Plain-language summary

The aim of this study is to use single-cell sequencing technology to explore neuroendocrine neoplasm (NEN) molecular biological characteristics, tumor heterogeneity and cell subtypes. Besides. NEN models are constructed for basic research, including primary cell lines, organoids, and animal models.

Who can participate

Age range18 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Between the ages of 18 and 80, with any gender;
✓. Physical fitness score ECOG 0～1 points;
✓. The diagnosis is considered as gastrointestinal pancreatic neuroendocrine tumor or pancreatic ductal adenocarcinoma;
✓. There is no obvious contraindication to surgery or biopsy;
✓. Uncompensated liver cirrhosis, acute and chronic hepatitis and other diseases;
✓. No history of other biliary tract related diseases;
✓. Volunteer to participate and sign the informed consent form. -

Exclusion criteria

✕. Patients with non-gastrointestinal pancreatic neuroendocrine tumors or pancreatic ductal adenocarcinoma confirmed pathologically;
✕. Suffer from other digestive system diseases, such as irritable bowel syndrome, inflammatory bowel disease;
✕. Those who have incomplete follow-up data or refuse to accept follow-up;
✕. Patients with other malignant tumors or hematological diseases; -

What they're measuring

Bioinformatics analysis of single-cell sequencing results

Timeframe: Half a year

Model construction

Timeframe: One year

Trial details

NCT IDNCT04927611

SponsorFudan University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2022-06

Contact for this trial

Xianjun Yu, MD, PhD

+86-13801669875 yuxianjun@fudanpci.org

View on ClinicalTrials.gov More Neuroendocrine Neoplasm trials