Effects of Iloprost on Oxygenation During One-lung Ventilation in Supine-positioned Patients (NCT04927039) | Clinical Trial Compass
UnknownNot Applicable
Effects of Iloprost on Oxygenation During One-lung Ventilation in Supine-positioned Patients
South Korea60 participantsStarted 2021-06-24
Plain-language summary
One-lung ventilation (OLV) is essential during mediastinal mass excision. However, OLV induces a drastic increase of intrapulmonary shunt due to maintained pulmonary perfusion through the nonventilated lung. In addition, it is reported that supine positioning of patient during OLV, which is required during mediastinal mass excision, results in worse oxygenation than lateral decubitus positioning.
Iloprost is a prostaglandin analogue and when inhaled during OLV, it acts selectively on the pulmonary vasculature, reducing pulmonary vascular resistance of well-ventilated lung and thereby alleviating ventilation-perfusion mismatch. The purpose of this study is to evaluate the effects of inhaled iloprost on oxygenation during one-lung ventilation in patients undergoing mediastinal mass excision.
Who can participate
Age range20 Years – 80 Years
SexALL
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Inclusion criteria
✓. Patients scheduled for Video-assisted thoracoscopic surgery (VATS) mediastinal mass excision
✓. Patient age from 20 to 80
✓. American Society of Anaesthesiologists (ASA) physical status classification II\~III
Exclusion criteria
✕. Chronic obstructive pulmonary disease (COPD) with Forced expiratory volume in 1 second (FEV1) to Forced vital capacity (FVC) ratio \< 0.7 and percentage of predicted FEV1 ≤ 80%
✕. Diffusing capacity of carbon monoxide (DLCO) \< 80%